TABLE  3: CHOICE OF DRUG(S) ACCORDING TO PATIENT FACTORS 8 PATIENT  FACTOR CHLOROQUINE PROGUANIL MEFLOQUINE DOXYCYCLINE Infants and young  children Can be used, even in  infants. Can be used, even in  infants. Can be used in  children over 15kg. Use only in children  from 8 years of age. Pregnancy Regimen of choice  during pregnancy, even the first trimester. Regimen of choice  during pregnancy, even the first trimester. Add folic acid supplement at  5 mg/day. Contraindicated  during first trimester. Can be used from 4th month. Avoid use. Breastfeeding woman Can be used. Can be used. Contra-indicated. Avoid use. Porphyria Although rare, it may  cause porphyria. Can be used. Insufficient safety  data available. Avoid use. Insufficient  safety data available. Epilepsy Although rare, it may  cause seizures. Can be used. Contraindicated. May interact with  anticonvulsants resulting in prophylactic failures. Psychiatric  conditions Can be used. Rare  cases of psychosis reported. Can be used. Contraindicated. Can be used. Psoriasis May exacerbate  psoriasis. Can be used. Insufficient data. May exacerbate  psoriasis. Renal impairment Use with caution. Use with caution. Contraindicated.  Insufficient safety data available. Can be used. Individuals requiring  fine motor co-ordina-tion Can be used. Can be used. May cause spatial  disorientation. If so, avoid use. Can be used. Other medications Use with caution  together with warfarin. Use with caution  together with warfarin. Use with caution  together with:     beta blockers, calcium antagonists, quinidine,  quinine, chloroquine, valproic acid, halofantrine. Interactions with  oral contraceptives, warfarin, anticonvulsants, iron supplements and antacids.  The  guidelines are endorsed by the Medical Association of South Africa. Compiled by the Department of Health in  collaboration with the Subcommittee for Chemoprophylaxis and Therapy of the National  Malaria Advisory Group. October 1996